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KMID : 1123920120260030330
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Korean Journal of Oriental Physiology and Pathology
2012 Volume.26 No. 3 p.330 ~ p.337
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Effect of Schisandrae Chinensis Fructus on Keratinocyte Damage by UV Irradiation
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Park Hyung-Hoon
Lee Jang-Suk
Yun Hyuk
Hwang Bang-Yeon
Chong Myong-Soo
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Abstract
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This study was performed to assess the Effect of SCF(Schisandrae Chinensis Fructus) on Keratinocyte Damage by UV irradiation. The effect of SCF were determined in UV irradiated HaCaT. We measured LDH release and NO release from HaCaT to elucidate the effect of SCF. And iNOS, TNF-α, COX-2, Bax, Bcl-2, Bcl-xL, c-jun, c-fos gene expression were determined in HaCat using real time PCR method. The results are as follows. SCF inhibited LDH-release, NO production in UV irradiated HaCaT. SCF increased the gene expression Bax, Bcl-2 and Bcl-xL protein in UV irradiated HaCaT. SCF suppressed the gene expression TNF-α in UV irradiated HaCaT. SCF suppressed the gene expression iNOS, c-fos, and c-jun in UV irradiated HaCaT. SCF not affected the suppression of the gene expression COX-2 in UV irradiated HaCaT. The study showed SCF inhibited the cell damage in UV irradiated HaCaT.
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KEYWORD
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schizandrae chinensis fructus, HaCaT keratinocyte, UV irradiation
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